Prepare the smoker for indirect heating, set the temperature to 275 degrees F.
Take the fish and wash it well. Then look for bones in there, if there are any remove them and prepare the fish for getting a coat of spices.
In a small bowl, add lemon juice, oil, garlic powder, salt, and lemon pepper. Mix everything well.
Place the fish fillets in a pan, brush the mixture that you prepared for the tilapia fish. Make sure the fish is completely coated with the liquid mixture.
Place the fish on the smoker rack and place it in the smoker for 2 hours.
Once the tilapia is smoked and cooked. Remove it from the smoker and serve hot.